Specifications
Target
Alternative Names
CD86; CD86 molecule; B7-2; T-lymphocyte activation antigen CD86; cd86 antigen; membrane glycoprotein
Product Background
Antigen Description
CD86 is predominantly expressed on antigen presenting cells, and expression may also be induced on B-cells by activation.
Pathway
Adaptive Immune System; Autoimmune thyroid disease; CTLA4 inhibitory signaling; Cell adhesion molecules (CAMs); Costimulation by the CD28 family; Immune System; Rheumatoid arthritis; T cell receptor signaling pathway
Citations
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Mollov, JL; Lucas, CL; et al. Recipient Dendritic Cells, But Not B Cells, Are Required Antigen-Presenting Cells for Peripheral Alloreactive CD8+T-Cell Tolerance. AMERICAN JOURNAL OF TRANSPLANTATION 10:518-526(2010).
Smolewska, E; Stanczyk, J; et al. Distribution and clinical significance of blood dendritic cells in children with juvenile idiopathic arthritis. ANNALS OF THE RHEUMATIC DISEASES 67:762-768(2008).