Specifications
Immunogen
Native purified Cd86 from mouse LPS-activated B cells.
Applications
Application Notes
ELISA (1:10000) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
CD86; CD86 antigen; T-lymphocyte activation antigen CD86; activation B7-2 antigen; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1; B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2;
Product Background
Antigen Description
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Pathway
Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD28
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Barbosa, RR; Silva, SP; et al. Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 169:263-272(2012).
Schreiber, TH; Wolf, D; et al. Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. JOURNAL OF CLINICAL INVESTIGATION 120:3629-3640(2010).
COA
Certificate of Analysis
