Anti-CD86 monoclonal antibody, clone NtyiC8-3

Antibody Isotype

IgG2a

Clone

NtyiC8-3

Species Reactivity

Mouse

Immunogen

Native purified Cd86 from mouse LPS-activated B cells.

Conjugate

Application Notes

ELISA (1:10000) & The optimal working dilution should be determined by the end user.

Alternative Names

CD86; CD86 antigen; T-lymphocyte activation antigen CD86; activation B7-2 antigen; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1; B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2;

Entrez Gene ID

UniProt ID

Antigen Description

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

Pathway

Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD28