Product Overview
A DNA sequence encoding the SARS-CoV-2 (2019-nCoV) spike protein receptor binding domain together with subdomain 1 and subdomain 2 (Glu309-Ala684)
Target
SARS-CoV-2 Spike RBD
Molecular Weight
Predicted molecular weight 42.9kD
Endotoxin
<0.1 EU per ug of protein as determined by LAL method
Alternative Names
SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein
Storage
The protein is stable in a liquid state at -70°C for 12 months. Avoid repeated freeze-thaw cycles.
Ship
Recombinant proteins are provided as frozen liquid and will be shipped out with dry ice.
Introduction
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.
Keywords
SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein
Citations
Publication ()
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COA
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