Recombinant SARS-CoV-2 S1 [human Fc] (DAGC092)

Recombinant SARS-CoV-2 Spike Protein 1 from Human cells [human Fc]

Product Overview
A DNA sequence encoding the SARS-CoV-2 spike protein S1 was expressed with the Fc region of human IgG1 at the C-terminus.
Target
SARS-CoV-2 S1
Nature
Recombinant
Predicted N terminal
Val
Tag/Conjugate
Fc
Molecular Weight
The recombinant SARS-CoV-2 spike protein S1 consists of 908 amino acids and predicts a molecular mass of 101.7 kDa.
Endotoxin
<1.0 EU per μg protein as determined by the LAL method.
Alternative Names
SARS-CoV-2; coronavirus; SARS-CoV-2 S1; SARS-CoV-2 spike protein
Procedure
None
Purity
> 90 % as determined by SDS-PAGE.
Format
Lyophilized
Size
100 µg
Buffer
Lyophilized from sterile. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Preservative
None
Storage
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Ship
Shipped at ambient temperature.
Introduction
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
Keywords
SARS-CoV-2; coronavirus; SARS-CoV-2 S1; SARS-CoV-2 spike protein

Citations


Have you cited DAGC092 in a publication? Let us know and earn a reward for your research.

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

Online Inquiry

Name:
Phone: *
E-mail Address: *
Technology Interest:
Type of Organization:
Service & Products Interested: *
Project Description:

Related Products

Related Resources

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

Inquiry Basket