Product Overview
Recombinant SARS-CoV-2 S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685 is expressed.
Tag/Conjugate
Unconjugated
Molecular Weight
78.3 kDa
Alternative Names
SARS-CoV-2; coronavirus; SARS-CoV-2 S1; SARS-CoV-2 spike protein
Purity
Greater than 85% as determined by reducing SDSPAGE.
Buffer
Supplied as a 0.2 μM filtered solution of PBS, pH 7.4
Storage
Reconstituted protein solution should be stored at ≤ -20°C.
Ship
The product is shipped on dry ice pack.
Introduction
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
Keywords
SARS-CoV-2; coronavirus; SARS-CoV-2 S1; SARS-CoV-2 spike protein
Citations
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