A DNA sequence encoding the SARS-CoV-2 (2019-nCoV) spike protein receptor binding domain and subdomain (Arg319-Ser591)
Target
SARS-CoV-2 Spike RBD
Nature
Recombinant
Tag/Conjugate
His
Molecular Weight
Predicted molecular weight 31.8 KD
Endotoxin
<0.1 EU per ug of protein as determined by LAL method
Alternative Names
SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein
Purity
90% or above
Format
Liquid
Buffer
PBS
Preservative
None
Storage
The protein is stable in a liquid state at -70°C for 12 months. Avoid repeated freeze-thaw cycles.
Ship
Recombinant proteins are provided as frozen liquid and will be shipped out with dry ice.
Introduction
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.
Keywords
SARS-CoV-2; coronavirus; SARS-CoV-2 spike RBD; SARS-CoV-2 spike protein
Citations
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COA
Certificate of Analysis
