Mouse CRP ELISA Kit (DE0061)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Size
96T
Sample
serum, plasma, tissue homogenates, cell culture supernatant, cell culture lysate and other biological fluids
Species Reactivity
Mouse
Intended Use
This kit is intended for quantitative detection of CRP in serum, plasma, tissue homogenates and other biological fluids.
Storage
4°C for 6 months
Precision
Intra-Assay: CV<8%
Inter-Assay: CV<10%
Detection Range
39.063-2500pg/ml
Sensitivity
23.438pg/ml
General Description
C-reactive protein (CRP) is a protein found in the blood, the levels of which rise in response to inflammation(i.e. C-reactive
protein is an acute-phase protein). Its physiological role is to bind to phosphocholineexpressed on the surface of dead or dying
cells (and some types of bacteria) in order to activate thecomplement system via the C1Q complex.

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References


Evaluation of the novel coronavirus disease in Turkish children: Preliminary outcomes

PEDIATRIC PULMONOLOGY

Authors: Yilmaz, Kamil; Gozupirinccioglu, Ayfer; Aktar, Fesih; Akin, Alper; Karabel, Musemma; Yolbas, Ilyas; Uzel, Veysiye Hulya; Sen, Velat

Background The novel coronavirus disease (Covid-19) can progress with mild to moderate or self-limiting clinical findings in children. The aim of this study was to investigate the disease features of Covid-19 in Turkish children. Methods Children diagnosed by the method of real-time reverse transcription-polymerase chain reaction for Covid-19 at the Dicle University Department of Pediatric, between April and June 2020, were evaluated. Hospital records were investigated retrospectively. Results One hundred and five patients children with the mean age of 108.64 +/- 65.61 months were enrolled in this study. The most common cause of transmission in pediatric patients was in contact with a family member diagnosed with COVID-19 (n = 91, 86.7%). The most common admission complaints were dry cough (n = 17, 16.2%), fever (n = 16, 15.2%), lassitude and fatigue (n = 14, 13.3%) respectively. More than 95% of all children with Covid-19 were asymptomatic, mild, or moderate cases. CRP was identified only independent factor associated with long duration of hospitalization. Conclusion The results of this study show the effect of Covid-19 on Turkish children. A clear understanding of the local epidemiology of corona virus infections and identification of risk factors are critical for the successful implementation of the prevention and control program.

Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study

INTERNAL AND EMERGENCY MEDICINE

Authors: Hu, Weihua; Lv, Xinke; Li, Chang; Xu, Yang; Qi, Yiding; Zhang, Zhuheng; Li, Mingxuan; Cai, Feina; Liu, Dan; Yue, Jiang; Ye, Maoqing; Chen, Qijian; Shi, Kailei

Background The worldwide spread of SARS-CoV-2 has infected millions of people leading to over 0.3 million mortalities. The disruption of sodium homeostasis, tends to be a common occurrence in patients with COVID-19. Methods and results A total of 1,254 COVID-19 patients comprising 124 (9.9%) hyponatremic patients (under 135 mmol/L) and 30 (2.4%) hypernatremic patients (over 145 mmol/L) from three hospitals in Hubei, China, were enrolled in the study. The relationships between sodium balance disorders in COVID-19 patients, its clinical features, implications, and the underlying causes were presented. Hyponatremia patients were observed to be elderly, had more comorbidities, with severe pneumonic chest radiographic findings. They were also more likely to have a fever, nausea, higher leukocyte and neutrophils count, and a high sensitivity C-reactive protein (HS-CRP). Compared to normonatremia patients, renal insufficiency was common in both hyponatremia and hypernatremia patients. In addition, hyponatremia patients required extensive treatment with oxygen, antibiotics, and corticosteroids. The only significant differences between the hypernatremia and normonatremia patients were laboratory findings and clinical complications, and patients with hypernatremia were more likely to use traditional Chinese medicine for treatment compared to normonatremia patients. This study indicates that severity of the disease, the length of stay in the hospital of surviving patients, and mortality were higher among COVID-19 patients with sodium balance disorders. Conclusion Sodium balance disorder, particularly hyponatremia, is a common condition among hospitalized patients with COVID-19 in Hubei, China, and it is associated with a higher risk of severe illness and increased in-hospital mortality.

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