hsCRP Rapid Test

The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with alpha-tocopherol (alpha-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with alpha-TOCO and/or TUMR post-TCM injection, significantly mitigated the increases in serum troponin T, creatine kinase-MB (CK-MB) as well as interleukin-6 (IL-6), interferon gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP). They also decline the elevation of caspase-3, vascular endothelial growth factor (VEGF) protein expression as well as DNA damage in cardiac tissues induced by TCM. The biochemical results were confirmed by histopathological investigation. Conclusion: The combination of the three antioxidants showed greater cardioprotective potential, compared to individual drugs. Therefore, this combination may be recommended as a complementary therapy to antagonize cardiac injury induced by different insults.

Children with end stage renal disease (ESRD) are liable to various health disorders that possibly impair their quality of life (QoL). Low dietary intake of Omega-3 fatty acids also called marine n-3 fatty acid (n-3 FA) may be associated with health problems which are among the leading causes of impaired QoL. The objective of this study was to assess the effect of omega-3 Fatty acid (n-3 FA) supplements on quality of life among children on dialysis and to evaluate its use regarding adequacy of dialysis and inflammatory markers. A prospective cohort study was conducted on 31 hemodialysis children. Quality of life was measured for patients and an equal number of matched controls using the PedsQL Inventory where the higher the score the poorer is the quality of life.n-3FAsupplementation had been given to the patients for 3 months to study its effects on QoL. Laboratory investigations like hemoglobin, lipid profile, inflammatory markers, and tests for adequacy of dialysis had been carried out. Patients had significantly higher QoL scores (42.22 +/- 13.31) than controls (22.70 +/- 1.31) (P < .001). Young ages showed higher score of physical functioning (18.23 +/- 4.22) than older ones (13.92 +/- 6.84) (P = .049). Females had significantly higher total QoL score (25.53 +/- 6.61) than males (20.06 +/- 7.09) (P = .010). The total QoL score was significantly lower post than pre administration of n-3FA (35.41 +/- 10.36 vs 42.22 +/- 13.31) (P < .001). Triglycerides and CRP were significantly lower post than pre n-3FA supplementation (160.64 +/- 32.55 vs 169.35 +/- 31.82) (P < .001) and (10.29 +/- 4.39 vs 11.19 +/- 4.83) (P = .006) respectively. Means of Kt/V and urea reduction ratio (URR) were significantly higher post (1.37 +/- 0.09, 70.0 +/- 5.99 respectively) than pre n-3FA (1.31 +/- 0.07 and 65.25 +/- 6.06 respectively) (P = .005, .001 respectively). Quality of life and adequacy of dialysis get improved aftern-3FAsupplementation among children on dialysis which encourages its testing for more patients to evaluate its long term effects and support its routine use.