Product Overview
AAV2 reference standards (empty capsids), purified AAV2 empty viral particles.
Tag/Conjugate
Unconjugated
Bio-activity
Titer: > 1x10^13 VG/mL
Alternative Names
AAV; AAV2; AAV 2; Adeno-associated virus; Adeno-associated virus 2; Adeno-associated virus type 2
Buffer
PBS with 0.01% Pluronic F-68
Introduction
Adeno-Associated Virus (AAV) is a nonpathogenic virus species that belongs to the Parvoviridae family. AAV is classified as small (25nm) and contains a single-stranded nonenveloped DNA genome. Infection with AAV occurs only with the help of other viruses, either herpesvirus or adenovirus (hence adeno-associated virus), causing only a very mild immune response in humans. There are twelve serotypes of human AAV but the number of nonhuman AAVs exceeds 100. AAV2 is the only mammalian DNA virus that is known to integrate in a specific site of the genome.
Keywords
AAV; AAV2; AAV 2; Adeno-associated virus; Adeno-associated virus 2; Adeno-associated virus type 2
Citations
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Q & A
Q: What purification method or QC analysis normally is provided with the material?
A: This AAV2 empty capsid is purified by CsCI ultracentrifuge. The capsid concentration is tested by ELISA.
Q: Are the reference particles empty capsids or partial capsid components?
A: The AAV reference particles are empty capsids composed of the full-length AAV structural proteins VP1, VP2, and VP3, identical to those in standard AAV vectors but without genomic material.
Customer Reviews
Le Guiner, C; Montus, M; et al. Forelimb Treatment in a Large Cohort of Dystrophic Dogs Supports Delivery of a Recombinant AAV for Exon Skipping in Duchenne Patients. MOLECULAR THERAPY 22:1923-1935(2014).
Xia, HJ; de Queiroz, TM; et al. Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 308:R370-R378(2015).
COA
Certificate of Analysis
