Anti-AAV2 Replicase monoclonal antibody (DMAB6345)

Recognizes AAV replicase proteins Rep 78, Rep 68, Rep 52 and Rep 40 in human AAV-2-infected cells. Cross-reactivity with AAV serotypes 1, 3, 4, 5, 6, 7, 8 ,9 and 10 (4,11 and 12 were negative). A weak cross-reactivity is seen in some human cell lines. Datasheet

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Specifications

Host Species
Mouse
Antibody Isotype
IgG1
Clone
A304.10
Species Reactivity
AAV
Immunogen
Recombinant AAV-2 Rep 78 protein, N-terminally truncated by 171 aa
Conjugate
unconjugated

Target

Alternative Names
AAV; AAV, Rep Protein; Adeno-Associated Virus, Rep Protein; Parvovirinae; Dependovirus; adeno-associated virus

Product Background

Antigen Description
Mab A304. 10 reacts with Rep proteins (Rep78, Rep68, Rep52 and Rep40) of human AAV-2-infected cells, and also with serotypes 1,3,4,5 and 6. Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. AAV can infect both dividing and non-dividing cells and may incorporate its genome into that of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Recent human clinical trials using AAV for gene therapy in the retina have shown promise.

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