Anti-PF4 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

KLH conjugated synthetic peptide derived from human CXCL4/PF4

Conjugate

Application Notes

WB: 1:100-500; ELISA: 1:500-1000; IHC-P: 1:100-500; IF: 1:100-500;

Alternative Names

PF4; platelet factor 4; PF-4; CXCL4; SCYB4; platelet factor 4; iroplact; oncostatin-AC-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4

Entrez Gene ID

UniProt ID

Antigen Description

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7 transmembrane, G protein coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non ELR types based on the presence or absence of a glu leu arg sequence adjacent and N terminal to the CXC motif.

Pathway

CXCR3-mediated signaling events; Cell surface interactions at the vascular wall; Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors)