Platelet factor 4 (PF4) is a member of the CXC chemokine family. Human and mouse PF4 share 64% identity. PF4 is involved in monocyte survivial and differentiation into macrophages, and it has anti-angiogenic activity.
Pathway
CXCR3-mediated signaling events; Cell surface interactions at the vascular wall; Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); Common Pathway; Cytokine-cytokine receptor interaction; Formation of F
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