Specifications
Immunogen
E. coli-derived recombinant human CXCL4/PF4. Glu32-Ser101 Accession Number P02776.2
Applications
Application Notes
ELISA Capture: 2-8 μg/mL; ELISA Detection: 0.1-0.4 μg/mL
We recommend the following for sandwich ELISA (Capture - Detection):
DCABY-4093 -
DPABY-408
Target
Alternative Names
PF4; platelet factor 4; PF-4; CXCL4; SCYB4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4;
Product Background
Antigen Description
Platelet factor 4 (PF4) is a member of the CXC chemokine family. Human and mouse PF4 share 64% identity. PF4 is involved in monocyte survivial and differentiation into macrophages, and it has anti-angiogenic activity.
Pathway
CXCR3-mediated signaling events; Cell surface interactions at the vascular wall; Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); Common Pathway; Cytokine-cytokine receptor interaction; Formation of F
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Thiele, T; Althaus, K; et al. Heparin-induced thrombocytopenia. INTERNIST 51:1127-+(2010).
Jaax, ME; Greinacher, A; et al. Management of heparin-induced thrombocytopenia. EXPERT OPINION ON PHARMACOTHERAPY 13:987-1006(2012).
COA
Certificate of Analysis
