Alternative Names
Platelet Factor 4; PF-4; Oncostatin-A; PF4; CXCL4; SCYB4
Purity
> 95% , as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements.
Buffer
20mM PB, 150mM NaCl, pH7.4
Storage
Store at -20°C to -80°C
Introduction
Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.
Antigen Description
Recombinant Human C-X-C Motif Chemokine 4 (PF4) is produced by Mammalian expression system and the target gene encoding Glu32-Ser101 is expressed with a 6His tag at the C-terminus.
Keywords
Platelet factor 4; PF4; CXC chemokine; Chemokine (C-X-C motif) ligand 4
Citations
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Kannan, M; Ahmad, S; et al. Characterization of HIT-associated Heparin-PF4 antibodies in Asian indians: Relevance to inflammatory markers. FASEB JOURNAL 18:A195-A196(2004).
Ahmad, S; et al. Heparin-induced thrombocytopenia: Impact of bovine versus porcine heparin in HIT pathogenesis. FRONTIERS IN BIOSCIENCE 12:3312-3320(2007).
COA
Certificate of Analysis
