Mouse anti Staphylococcus aureus SEB monoclonal antibody, clone Mab20

Staphylococcus aureus is a common bacterium that can cause infections in both healthy and immunocompromised individuals. It possesses virulence factors known as staphylococcal superantigens (SAgs). SAgs have the ability to interact with certain T cell receptors and MHCII molecules, leading to immune system activation. Different strains of S. aureus can produce various SAgs, but most strains can produce toxic shock syndrome toxin-1 (TSST-1), staphylococcal enterotoxin B (SEB), and staphylococcal enterotoxin C (SEC).

SEB is heat-stable and resistant to digestive enzymes in the stomach, which allows it to cause illness even when present in contaminated food. Upon ingestion, SEB acts as a superantigen, meaning it stimulates a massive immune response by directly binding to specific receptors on T cells and antigen-presenting cells. This binding leads to the activation and proliferation of a large number of T cells, resulting in the release of various pro-inflammatory cytokines, such as IL-1, IL-2, and TNF-alpha. The excessive release of these cytokines leads to the symptoms of staphylococcal food poisoning, which typically include rapid onset nausea, vomiting, abdominal cramps, and diarrhea. SEB can also have broader implications beyond food poisoning. In experimental settings, inhalation or injection of SEB has been shown to induce acute respiratory distress syndrome (ARDS) and systemic toxic shock-like reactions.

Figure 1. Cells and mediators participating in superantigen-induced toxic shock.
(Source: Krakauer, T. et al., 2016)

SEB can cause severe poisoning and pose a threat to human health. Therefore, it is crucial to detect this toxin in food and other environments. Anti-Staphylococcus Enterotoxin B (SEB) monoclonal antibody is a type of antibody specifically designed to target and bind to the Staphylococcus aureus enterotoxin B protein. It can be employed in immunoassays, such as enzyme-linked immunosorbent assays (ELISA), lateral flow assays, or immunoblotting, to detect the presence of SEB in various samples, including food, environmental samples, or clinical specimens. The specificity of anti-SEB monoclonal antibodies allows for the accurate identification and quantification of SEB, aiding in the diagnosis of SEB-related illnesses and foodborne infections. Additionally, these antibodies can be used in immunotherapy approaches to neutralize the effects of SEB by blocking its interaction with host immune cells and preventing the resulting hyperactivation of the immune system.

Anti-Staphylococcus Enterotoxin B monoclonal antibody
Anti-S. aureus Enterotoxin B (SEB) monoclonal antibody
Anti-Staphylococcus aureus EntB monoclonal antibody
Anti-Staphylococcus aureus Enterotoxin type B monoclonal antibody