S. aureus Enterotoxin Type B Toxoid (DAGB111)

S. aureus Enterotoxin Type B Toxoid, native protein from S. aureus

Nature
Native
Tag/Conjugate
Unconjugated
Endotoxin
The endotoxin content, determined using a kinetic chromogenic LAL assay, is approximately 2 EU/mg.
Alternative Names
EntB; Enterotoxin type B; SEB; Staph. aureus Enterotoxin B ; entB; entC1
Procedure
None
Format
Lyophilized power
Size
0.25 mg
Preservative
None
Storage
Store at 2-8°C prior to reconstitution. Following reconstitution, aliquot and freeze.
Reconstitution
When reconstituted with 500 μl water, contains 250 μg of Staphylococcal Enterotoxin Type B Toxoid in 0.1M Histidine, 0.1M Sodium Chloride, pH 7.0, with 5% Trehalose.
Antigen Description
Staphylococcal enterotoxins B (SEB) is described as a superantigen for its ability to bind to Major Histocompatibility Complex molecules on antigen presenting cells and stimulate a large population of T cells, producing an inappropriate flood of cytokines. Although they are important participants in an immune response, cytokines, when overproduced, lead to toxic shock. Recently SEB has been found to bind to another regulator of the T cell immune response, CD 28. When added to human peripheral blood cells, SEB produces large quantities of IL-2, TNF-A and INF-c. Native SEB toxin has been treated with formaldehyde to produce a toxoid which has reduced cytokine stimulating activity and immunogenicity when compared with the native toxin. Care must be taken in the design of experiments with the toxoid because although toxicity has been reduced, sufficient toxicity may remain to cause death under certain conditions. Both the toxin and toxoid are handled as Select Agents and Toxins.

Citations


Have you cited DAGB111 in a publication? Let us know and earn a reward for your research.

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

Online Inquiry

Name:
Phone: *
E-mail Address: *
Service & Products Interested: *
Project Description:
Verification Code: * Please input "diagnostics" as verification code.

Online Inquiry

  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket