Recombinant SARS-CoV-2 Spike RBD (D614G, E484K) (DAGC479)

Recombinant SARS-CoV-2 Spike RBD (D614G, E484K) from HEK293 Cells [His]

Product Overview
SARS-CoV-2 Spike protein S1 containing both D614G and E484K amino acid changes relative to the Wuhan-Hu-1 isolate. The D614G isolate has been reported to show increased virus transmissibility.
Target
SARS-CoV-2 Spike RBD
Nature
Recombinant
Predicted N terminal
Arg319
Tag/Conjugate
Fc
Molecular Weight
Expected Molecular Weight: 73 kDa
Observed Molecular Weight: 130 kDa
Alternative Names
SARS-CoV-2 Spike RBD; SARS-CoV-2; SARS-CoV-2 S1 RBD; SARS-CoV-2 Spike; SARS-CoV-2 RBD
Procedure
None
Purity
>90%
Format
Liquid
Size
100ug, 500ug
Buffer
DPBS
Preservative
None
Storage
Store it at -80°C.
Introduction
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
Keywords
SARS-CoV-2 Spike RBD; SARS-CoV-2; SARS-CoV-2 S1 RBD; SARS-CoV-2 Spike; SARS-CoV-2 RBD

Citations


Have you cited DAGC479 in a publication? Let us know and earn a reward for your research.

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

Online Inquiry

Name:
Phone: *
E-mail Address: *
Technology Interest:
Type of Organization:
Service & Products Interested: *
Project Description:

Related Products

Related Resources

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

Inquiry Basket