Product Overview
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Molecular Weight
32.4 kDa
Alternative Names
ATP-dependent Clp protease ATP-binding subunit ClpC; SAV0525
Purity
> 90% as determined by SDS-PAGE
Format
Liquid or Lyophilized powder
Concentration
Batch dependent - please inquire should you have specific requirements.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
Storage
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Introduction
ClpC is an AAA+ ATPase chaperone in Staphylococcus aureus that forms hexameric complexes with protease subunits (e.g., ClpP). It uses ATP hydrolysis to unfold and translocate damaged/misfolded proteins into ClpP for degradation, maintaining proteostasis during stress (e.g., heat, antibiotics). ClpC also regulates virulence factors (e.g., toxin secretion) and activates key adaptor proteins like MecA for β-lactam resistance . Essential for bacterial survival, it represents a target for cyclomarin-type antibiotics that disrupt proteolysis, sensitizing MRSA to host defenses.
Keywords
Staphylococcus aureus ATP-dependent Clp protease ATP-binding subunit ClpC; SAV0525
Citations
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