Product Overview
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Molecular Weight
49.6 kDa
Alternative Names
Foldase protein PrsA; prsA; SACOL1897; EC:5.2.1.8
Purity
> 90% as determined by SDS-PAGE
Format
Liquid or Lyophilized powder
Concentration
Batch dependent - please inquire should you have specific requirements.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
Storage
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Introduction
Foldase protein PrsA is a membrane-anchored lipoprotein in Staphylococcus aureus that acts as a chaperone for post-translocational protein folding. It stabilizes and facilitates the secretion of virulence factors, notably protein A (SpA), by directly interacting with its N- and C-terminal domains. Deletion of prsA reduces SpA secretion, stability, and immunoglobulin-binding capacity, impairing immune evasion. PrsA also dimerizes via these domains, enhancing its function. Recombinant PrsA is expressed in E. coli, yeast, and baculovirus systems for mechanistic studies. Targeting PrsA disrupts virulence, offering therapeutic potential against antibiotic-resistant infections.
Keywords
Staphylococcus aureus Foldase protein PrsA; prsA; SACOL1897; EC:5.2.1.8
Citations
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