Product Overview
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Molecular Weight
29.6 kDa
Alternative Names
Holo-[acyl-carrier-protein] synthase; Holo-ACP synthase; 4'-phosphopantetheinyl transferase AcpS; acpS; dpj; SAR2159; EC:2.7.8.7
Purity
> 90% as determined by SDS-PAGE
Format
Liquid or Lyophilized powder
Concentration
Batch dependent - please inquire should you have specific requirements.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
Storage
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Introduction
Holo-[acyl-carrier-protein] synthase (AcpS) is an essential cytoplasmic enzyme (EC 2.7.8.7) in Staphylococcus aureus that activates the fatty acid synthase (FAS II) system. It transfers the 4'-phosphopantetheine group from coenzyme A to a serine residue on apo-acyl carrier protein (ACP), converting it to functional holo-ACP. This post-translational modification enables ACP to shuttle growing fatty acid chains during membrane lipid biosynthesis. Recombinant AcpS is expressed in E. coli, yeast, or baculovirus systems with >85% purity for biochemical studies and inhibitor screening. Targeting AcpS disrupts lipid metabolism, offering antibacterial potential against drug-resistant strains.
Keywords
Staphylococcus aureus Holo-[acyl-carrier-protein] synthase; Holo-ACP synthase; 4'-phosphopantetheinyl transferase AcpS; acpS; dpj; SAR2159; EC:2.7.8.7
Citations
Publication ()
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