Syntheses of 2-Deoxy-2,3-didehydro-N-acetylneuraminic Acid Analogues Modified by alpha-Acylaminoamido Groups at the C-4 Position Using Isocyanide-Based Four-Component Coupling and Biological Evaluation as Inhibitors of Human Parainfluenza Virus Type 1
CHEMICAL & PHARMACEUTICAL BULLETIN
Authors: Nishino, Reiko; Hayakawa, Takuya; Takahashi, Tadanobu; Suzuki, Takashi; Sato, Masayuki; Ikeda, Kiyoshi
Abstract
Novel sialidase inhibitors 11 having an alpha-acylaminoamido group at the C-4 position of Neu5Ac2en 1 against human parainfluenza virus type 1 (hPIV-1) were synthesized using one-pot isocyanide-based four-component condensation, and their inhibitory activities against hPIV-1 sialidase were studied. Compound 11b showed inhibitory activity (IC50=5.1mM) against hPIV-1 sialidase. The degree of inhibition of 11b was much weaker than that of 1 (IC50=0.3 mM).
Mononuclear pivalates of metals of the first transition series
RUSSIAN JOURNAL OF COORDINATION CHEMISTRY
Authors: Ovcharenko, V. I.; Fursova, E. Yu.; Romanenko, G. V.
Abstract
The synthesis and structures of mononuclear Ni(II), Co(II), Mn(II), and Cu(II) pivalates isolated as complex salts NBu4[M(Piv)(3)] ((NBu4)(+) is tetrabutylammonium cation, Piv(-) is pivalate anion) and polynuclear complexes [Ni-6(L)(2)(HL)(2)(Piv)(6)(HPiv)(8)], (NBu4)(2)[Co-4(Piv)(8)(AcO)(2)(H2O)(4)], NBu4[Co-2(Piv)(5)(H2O)(2)], and (NBu4)(2)[Cu-4(Piv)(8)(AcO)(2)(H2O)(2)] (L2-, HL-, and AcO- is lactic acid dianion, lactic acid monoanion, and acetate anion, respectively) are discussed. The formation of the compounds is detected during the development of the synthesis of NBu4[M(Piv)(3)].