Anti-PIV type 2 Monoclonal antibody, Clone 1242

Human parainfluenza-1 virus (hPIV-1) infections are a major cause of respiratory illness in young children. While children and adults are each susceptible to hPIV-1 infection, the clinical symptoms in adults are mild and hospitalizations are rare. One explanation for the differences in disease severity is that immune memory responses are simply inferior in children as compared to adults and cannot counter virus growth. Alternatively, it has been suggested that immune (particularly T-helper (T-H) cell) responses toward respiratory viruses are superior in children versus older individuals, and that these responses contribute to, rather than protect from, disease symptoms. As a test of these possibilities, we analyzed hPIV-1-specific T-helper (T-H) and B-cell memory responses among individuals of various ages, including children hospitalized with hPIV-1-induced croup. Experiments revealed: (t) hPIV-1-specific B-cell and class-II restricted T-H-cell proliferative responses were present in all tested adults. (2) T-H-cells responded to internal viral proteins as well as to the external glycoprotein, hemagglutinin-neuraminidase. (3) Immune responses were highly cross-reactive with Sendai virus. (4) Memory B-cell and T-H-cell responses were extremely poor in young children, inclusive of children tested upon hospital entry for hPIV-1-induced croup, In total, results did not support the theory that naturally induced hPIV-specific memory responses cause respiratory illness. Rather, results showed a correlation between memory and a good clinical outcome and highlighted Sendai virus as a strong candidate for an hPIV-1 vaccine. (C) 1994 Academic Press, Inc.

The reaction of nickel pivalate Ni-9(OH)(6)(Piv)(12)(HPiv)(4) (Piv is anion of pivalic acid) and triethylenetetraamine (L-1) (Ni : L-1 = 1 : 1) in MeCN with following addition of isophthalaldehyde (L-2, L-1 : L-2 = 1 : 1) results in the formation of Ni2L3(Piv)(4) (I), containing new macrocyclic ligand L-3 formed as a result of [2+2] condensation of L-1 with L-2. The new compound was characterized by single crystal X-ray diffraction and magnetic measurements.