The beta 2 integrin may be associated with the integrin alphaL, alphaX or alphaM subunits. CD18 is expressed by all leucocytes. Mouse anti Rat CD18 antibody has been shown to inhibit homotypic aggregation of PHA blasts. It also blocks binding of rat lymphocytes to purified rat ICAM-1.
Pathway
Adaptive Immune System; Cell adhesion molecules (CAMs); Cell surface interactions at the vascular wall; Epstein-Barr virus infection; Extracellular matrix organization; HTLV-I infection; Hemostasis; Immune System; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Integrin-mediated cell adhesion; Leukocyte transendothelial migration; Malaria; Natural killer cell mediated cytotoxicity; Rap1 signaling pathway; Regulation of actin cytoskele
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