Anti-ITGB2 monoclonal antibody, clone N29/3

Antibody Isotype

IgG2a

Clone

N29/3

Species Reactivity

Mouse

Immunogen

Mouse cytotoxic T cell glycoproteins.

Conjugate

Application Notes

Flow Cyt: 1 μg/ml; ICC/IF: 1/300.

Alternative Names

ITGB2; integrin beta 2; integrin beta-2; Mac-1 beta; macrophage antigen-1 beta; complement receptor C3 subunit beta; lymphocyte function associated antigen 1; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; 2E6; LAD; Cd18; Lfa1; MF17;

Entrez Gene ID

UniProt ID

Antigen Description

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.

Pathway

Adaptive Immune System, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Focal Adhesion, organism-specific biosystem;