Anti-ITGB2 monoclonal antibody, clone 645DU7.3.2

Antibody Isotype

IgG1

Clone

645DU7.3.2

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:500-8000

Alternative Names

ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD_antigen=CD18; Flags: Precursor

Entrez Gene ID

UniProt ID

Antigen Description

The product of this gene belongs to the integrin betachain family of proteins. Integrins are integral cell-surfaceproteins composed of an alpha chain and a beta chain. This geneencodes the integrin beta chain beta 2. A given chain may combinewith multiple partners resulting in different integrins. Forexample, beta 2 combines with the alpha L chain to form theintegrin LFA-1, and combines with the alpha M chain to form theintegrin Mac-1. Integrins are known to participate in cell adhesionas well as cell-surface mediated signalling. Defects in this geneare the cause of leukocyte adhesion deficiency type I (LAD1). Twotranscript variants encoding the same protein have been identifiedfor this gene.

Pathway

Adaptive Immune System; Amoebiasis; CXCR3-mediated signaling events; Cell adhesion molecules (CAMs); Cell surface interactions at the vascular wall; Extracellular matrix organization; Focal Adhesion; HIF-1-alpha transcription factor network;