General Notes
This product (Catalog No. DPABH-02621) is a rabbit-derived polyclonal antibody raised against human HSPA8, targeting the amino acid region 534–615 of the protein. This antibody exhibits cross-reactivity with Human HSPA8 from mouse and rat. It has been affinity purified by Protein A. HSPA8, also known as heat shock protein family A (Hsp70) member 8 or HSC70 (heat shock cognate 70), is a constitutively expressed gene that encodes a 70-kDa molecular chaperone protein essential for maintaining cellular proteostasis in eukaryotic cells. This protein, highly conserved across species and comprising up to 1-2% of total cellular protein content, functions primarily in an ATP-dependent manner to assist in the folding of nascent polypeptides, prevent protein aggregation, and facilitate the disassembly of protein complexes such as clathrin-coated vesicles during endocytosis. Unlike stress-inducible HSP70 family members, HSPA8 maintains basal expression levels ubiquitously, with particularly high abundance in tissues like the brain, kidney, and spleen, underscoring its role as a housekeeping chaperone critical for viability—as evidenced by the embryonic lethality of Hspa8 knockout in mice.
DPABH-02621 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-02621 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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