Specifications
Species Reactivity
Mouse, Rat, Sheep, Rabbit, Chicken, Guinea pig, Hamster, Cow, Dog, Human, Pig, Monkey
Immunogen
Full length hamster Hsc70 protein.
Applications
Application Notes
Flow Cyt: 10 μg/ml.
Target
Alternative Names
HSPA8; heat shock protein 8; heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8; HSC70;
Product Background
Antigen Description
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.
Citations
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Eckenrode, SE; Ruan, QG; et al. Gene expression profiles define a key checkpoint for type 1 diabetes in NOD mice. DIABETES 53:366-375(2004).
Elliott, RMA; Lloyd, RE; et al. Effects of HSPA8, an evolutionarily conserved oviductal protein, on boar and bull spermatozoa. REPRODUCTION 137:191-203(2009).
COA
Certificate of Analysis
