Anti-Salmonella Polyclonal antibody

Background: Pseudomonas aeruginosa and nontyphoidal Salmonella (NTS) species may cause enteric illness with sepsis in infancy. The clinical predictors distinguishing the two pathogens have not been comprehensively evaluated in this population in Taiwan. Methods: A retrospective matched case-control study was conducted in a teaching hospital in southern Taiwan from January 1, 2003 to January 30, 2019. The patients with community-acquired P. aeruginosa sepsis were matched at a ratio of 1:2 by age and gender with controls (who developed NTS sepsis). Results: A total of 21 infants with community-acquired P. aeruginosa sepsis were identified; of these, 12 (57.1%) were male, and the mean I standard deviation of age was 6.95 +/- 12.47 months. Two independent predictors indicative of P. aeruginosa sepsis, as identified by multivariate analysis using conditional logistic regression, were hemoglobin level (Hb) (matched odds ratio [mOR], 0.155; 95% confidence interval [CI], 0.027-0.900; p = 0.038) and platelet count (mOR, 0.988, 95% CI, 0.976-1.000; p = 0.049). The areas under the receiver operating characteristic (ROC) curves of Hb and platelet count for P. aeruginosa sepsis prediction were 0.855 and 0.803, respectively. With cut-off values for Hb of 10.7 g/dL and platelet count of 173,000/mu L, the predictors had maximal diagnostic accuracy. Conclusion: Most patients with P. aeruginosa sepsis are less than one year old. A lower hemoglobin level and a lower platelet count are significant predictors of P. aeruginosa sepsis. These findings should help to reshape the policy of empirical antibiotics in infants with sepsis. Copyright (C) 2020, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.

The biological proprieties of mucilaginous polysaccharides (PSc) and their soluble fraction (SF) extracted from Tossa jute leaves (Corchorus olitorius L.) using an ethanol precipitation method were studied. The results showed that PSc had higher total polyphenols and flavonoids and greater antioxidant activities than SF. At 1.5 mg/ml PSc, the antioxidant activities were about 90% against 1,1-diphenyl-2-picryl hydrazyl radical (DPPH.), 78% against lipid peroxidation and 69% against beta-carotene. The PSc with a FRAP assay at the same concentration showed an effective protection against hydroxyl radicals and DNA breakage. Furthermore, the extracted PSc had a wide spectrum of antibacterial activities against all bacteria tested (Gram+ and Gram-) while SF was effective against Klebsiella pneumoniae and Salmonella enterica at 25 mg/ml. The overall data suggested that this natural PSc may be used as a competitive antioxidant and antimicrobial additive in food and in medicinal preparations.