Anti-eIF4EBP1 monoclonal antibody, clone MAAG5421

Name: Anti-eIF4EBP1 monoclonal antibody, clone MAAG5421
SKU: CAB-7614MH
Rating: 5 (1 reviews)

Mouse anti-Human eIF4EBP1 monoclonal antibody for ELISA, WB

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG1

Clone

MAAG5421

Species Reactivity

Human

Immunogen

Purified recombinant fragment of 4EBP1 expressed in E. Coli.

Conjugate

Unconjugated

Applications

Application Notes

WB: 1:10000-50000

Target

Alternative Names

EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; 4E BP1; PHAS I; phosphorylated heat and acid stable protein regulated by insulin 1; eIF4E-binding protein 1; phosphory

Entrez Gene ID

1978

UniProt ID

Q13541

Product Background

Antigen Description

4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1),also called LF4EBP1/BP-1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent n the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind trongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP inase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 inding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. lthough, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.

Pathway

AMPK signaling, organism-specific biosystem; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem;

Citations