Anti-eIF4EBP1 monoclonal antibody, clone 0F23E0

Name: Anti-eIF4EBP1 monoclonal antibody, clone 0F23E0
SKU: DCABH-11388
Rating: 5 (1 reviews)

Mouse anti-Human eIF4EBP1 monoclonal antibody for WB, ELISA

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COA

SDS

Datasheet

Summary

Specifications

Clone

0F23E0

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human EIF4EBP1.

Conjugate

Unconjugated

Applications

Application Notes

WB (1:500-1:2000); ELISA (1:10000) & The optimal working dilution should be determined by the end user.

Target

Alternative Names

EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; 4E BP1; PHAS I; phosphorylated heat and acid stable protein regulated by insulin 1; eIF4E-binding protein 1; phosphoryl

Entrez Gene ID

1978

UniProt ID

Q13541

Product Background

Antigen Description

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5 end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Pathway

AMPK signaling, organism-specific biosystem; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem;

Citations