This gene encodes one member of a family of translationrepressor proteins. The protein directly interacts with eukaryotictranslation initiation factor 4E (eIF4E), which is a limitingcomponent of the multisubunit complex that recruits 40S ribosomalsubunits to the 5' end of mRNAs. Interaction of this protein witheIF4E inhibits complex assembly and represses translation. Thisprotein is phosphorylated in response to various signals includingUV irradiation and insulin signaling, resulting in its dissociationfrom eIF4E and activation of mRNA translation. [provided byRefSeq].
Pathway
AMPK signaling; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S; Acute myeloid leukemia; Alpha6-Beta4 Integrin Signaling Pathway; BDNF signaling pathway; Cap-dependent Translation Initiation; ErbB signaling pathway; Eukaryotic Translation Initiation;
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