Anti-eIF4EBP1 monoclonal antibody (CABT-33465MH)

Mouse anti-Human eIF4EBP1 monoclonal antibody for ELISA, IHC-P, WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
22H23D22
Species Reactivity
Human
Immunogen
Ni-NTA purified truncated recombinant eIF4EBP1 expressed in E. Coli strain BL21 (DE3)
Conjugate
Unconjugated

Applications


Application Notes
ELISA: 1/10000;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; 4E BP1; PHAS I; phosphorylated heatand acid stable protein regulated by insulin 1
Entrez Gene ID
UniProt ID

Product Background


Pathway
AMPK signaling, organism-specific biosystem; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-s

Citations


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References


Jankowska-Anyszka, M; Lamphear, BJ; et al. Multiple isoforms of eukaryotic protein synthesis initiation factor 4E in Caenorhabditis elegans can distinguish between mono- and trimethylated mRNA cap structures. JOURNAL OF BIOLOGICAL CHEMISTRY 273:10538-10542(1998).
Dudkin, L; Dilling, MB; et al. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. CLINICAL CANCER RESEARCH 7:1758-1764(2001).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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