Anti-eIF4EBP1 monoclonal antibody, clone 22H23D22

Antibody Isotype

IgG1

Clone

22H23D22

Species Reactivity

Human

Immunogen

Ni-NTA purified truncated recombinant eIF4EBP1 expressed in E. Coli strain BL21 (DE3)

Conjugate

Application Notes

ELISA: 1/10000;

Alternative Names

EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; 4E BP1; PHAS I; phosphorylated heatand acid stable protein regulated by insulin 1; 4E-BP1; 4EBP1; 4EBP1_HUMAN; BP 1; eI

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported.

Pathway

AMPK signaling, organism-specific biosystem; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; ErbB signaling pathway, organism-specific biosystem; ErbB signaling pathway, organism-s