Specifications
Immunogen
EIF4EBP1 (AAH04459, 1 a.a. ~ 119 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Target
Alternative Names
eukaryotic translation initiation factor 4E binding protein 1; 4EBP1; 4E-BP1; BP-1; PHAS-I; MGC4316; Phosphorylated heat- and acid-stable protein regulated by insulin 1; eukaryotic translation initiation factor 4E-binding protein 1; eIF4E-binding protein
Product Background
Antigen Description
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5" end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Mouse monoclonal antibody raised against a full-length recombinant EIF4EBP1.
Pathway
AMPK signaling, organism-specific biosystem; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem
Citations
Publication ()
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COA
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