General Notes
This product (Catalog No. CABT-L1291W) is a mouse-derived monoclonal antibody raised against human PKM2. Pyruvate kinase M2 (PKM2) is a key enzyme in glycolysis that catalyzes the irreversible conversion of phosphoenolpyruvate (PEP) to pyruvate, thereby generating adenosine triphosphate (ATP) in the final step of the glycolytic pathway. Encoded by the PKM gene on human chromosome 15 through alternative splicing, PKM2 is one of four mammalian pyruvate kinase isoforms (alongside PKL, PKR, and PKM1) and is characterized by its ability to exist in equilibrium between a high-activity tetrameric form and a low-activity dimeric form, regulated by allosteric effectors such as fructose-1,6-bisphosphate (FBP) and inhibitors like ATP or tyrosine phosphorylation. This isoform is predominantly expressed in embryonic tissues, proliferating cells, and most tumor cells, where it plays a central role in metabolic reprogramming to support rapid cell division and biosynthetic demands.
CABT-L1291W is suitable for use in ELISA(Cap), lateral flow immunoassay (LFIA), CLIA applications.
CABT-L1291W is supplied as a liquid formulation in PBS. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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