Product Overview
Biotinylated Human ACE2, Fc,Avitag is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Ser 740 (Accession # Q9BYF1-1). This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag.
Predicted N terminal
Gln 18
Molecular Weight
The protein has a calculated MW of 111.7 kDa. The protein migrates as 125-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per ug by the LAL method.
Alternative Names
ACE2; ACHE; ACE-2
Purity
>95% as determined by SDS-PAGE.
Buffer
Delivered as bulk protein in a 0.2 um filtered solution of 50 mM Tris, 150 mM NaCl, Arginine, pH7.5 with glycerol as protectant.
Storage
Store at -70°C or lower upon receipt.
Ship
Shipped with dry ice
Introduction
Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
Keywords
ACE2; ACHE; ACE-2
Citations
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