Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Pathway
ACE Inhibitor Pathway; Metabolism of Angiotensinogen to Angiotensins; Metabolism of proteins; Peptide hormone metabolism; Protein digestion and absorption; Renin-angiotensin system
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