Recombinant Human ACE2 [Fc] (DAGC152)

Recombinant Human ACE2 Protein from HEK293 Cells [Fc]

Product Overview
ACE2 Protein is Over-Expression Lysate. Human ACE2 Met 1-Ser 740 produced in HEK 293 Cells with Human IgG1 Fc, C-terminus tag(s).
Nature
Recombinant
Tag/Conjugate
Fc
Molecular Weight
110.3 kDa
Alternative Names
ACE2; angiotensin I converting enzyme 2; ACEH
Procedure
1 mM EDTA
Format
Lyophilized
Size
300 µg
Buffer
50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1 mM EDTA, 1% Triton X-100, 0.1% SDS, 1% Sodium deoxycholate, 1 mM PMSF
Preservative
None
Storage
Short-term store at 4°C. Long term store at -80°C. Avoid freeze-thaw cycles.
Reconstitution
Reconstitute in 200 ul distilled water and boil for 2-5 min. After reconstitution, recommended to aliquot and store at -80°C
Introduction
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
Keywords
ACE2; angiotensin I converting enzyme 2; ACEH

Data Examples


12% SDS-PAGE analysis profiles of purified DAGC152
Lane M: Protein Marker
Lane 1: DAGC152, Non-Reducing (2ug)
Lane 2: DAGC152, Reducing (2ug)

Citations


Have you cited DAGC152 in a publication? Let us know and earn a reward for your research.

Customer Reviews


Write a review, share your experiences with others and get rewarded !
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket
Product Name Cat. No. Applications Host Species Datasheet Price Add to Basket

References


Simmons, G; Bertram, S; et al. Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion. VIROLOGY 413:265-274(2011).
Kim, H; Hong, Y; et al. Functional analysis of the receptor binding domain of SARS coronavirus S1 region and its monoclonal antibody. GENES & GENOMICS 36:387-397(2014).

Online Inquiry

Name:
Phone: *
E-mail Address: *
Technology Interest:
Type of Organization:
Service & Products Interested: *
Project Description:

Related Products

Related Resources

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

Inquiry Basket