Alternative Names
AMH; Anti Mullerian Hormone Antigen; Anti Mullerian Hormone
Buffer
50 mM Tris, pH 8.0
Storage
Short Term: 2-8°C. Long Term: -20°C. Avoid repeated freezing and thawing.
Introduction
AMH is a tissue-specific TGF-β superfamily growth factor. Its expression is restricted to the Sertoli cells of fetal and postnatal testis, and to the granulosa cells of postnatal ovary. The human MIS gene encodes a 553 amino acid residue (aa) prepropeptide containing a signal a sequence (1- 24), a proregion (25-455), and the carboxylterminal bioactive protein (44-6553). MIS is synthesized and secreted as a disulfide-linked homodimeric pro-protein. Proteolytic cleavage is required to generate the N-terminal pro-region and the Cterminal bioactive protein, which remain associated in a noncovalent complex.
Antigen Description
Anti-Mullerian Hormone (AMH) (full length) recombinant protein expressed from E. coli, fused to his tag
Keywords
AMH; Anti Mullerian Hormone Antigen; Anti Mullerian Hormone
Citations
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Skaar, KS; Nobrega, RH; et al. Proteolytically Activated, Recombinant Anti-Mullerian Hormone Inhibits Androgen Secretion, Proliferation, and Differentiation of Spermatogonia in Adult Zebrafish Testis Organ Cultures. ENDOCRINOLOGY 152:3527-3540(2011).
Cabianca, G; Rota, A; et al. Expression of AMH in female fetal intersex gonads in the bovine. ANATOMIA HISTOLOGIA EMBRYOLOGIA-JOURNAL OF VETERINARY MEDICINE SERIES C 36:24-26(2007).