Anti Mullerian Hormone Antigen (16.7 kDa) [His]

Introduction: In our study we aimed to observe the protective effects of imatinib and ginkgo biloba (GB) on cisplatin (CP)-induced ovarian damage in rats. Methods: Thirty-two female rats were included and assigned to four groups. Group 1 had no medication. Their ovaries were removed for examination and the serum Anti-Mullerian hormone (AMH) levels were measured. Group 2 received a single dose of 7,5 mg/kg intramuscular CP. Group 3 received a single dose of 7.5 mg/kg oral imatinib and 30 minutes later, a single dose of 7.5 mg/kg intramuscular CP was administered. Group 4 received 80 mg/kg oral GB for 10 days. Sixty minutes after the first administration of the GB, a single dose of 7.5 mg/kg intramuscular CP was administered. The ovaries and serum AMH levels of the rats were assessed after 10 days of observation. Results: Comparing group 1 and 2 showed that the total histopathological ovarian damage scores increased in the latter (p=0.044). This group also had decreased primordial follicles, preantral follicles and serum AMH (p=0.001, p=0.004 and p<0.001 respectively). In group 3, total histopathological ovarian damage score increased (p=0.020), and a reduction in primordial follicles (p=0.008) and serum AMH levels (p<0.001) was observed. In group 4, total histopathological ovarian damage score increased (p=0.016) as in groups 2 and 3. There was also a reduction in primordial follicles, preantral follicles and serum AMH levels (p<0.00, p=0.010 and p<0.001 respectively). Conclusion: It was concluded that imatinib and GB were not effective in preventing CP-induced ovarian damage in rats.

Background: Vitamin D deficiency and infertility are two important health problems in Iran. Some studies suggest that vitamin D may influence Anti-Mullerian hormone (AMH) and antral follicle count (AFC) as an ovarian reserve. Objective: The present study aimed to investigate the impact of vitamin D on AMH serum concentrations/AFC. Materials and Methods: Three hundred and five infertile women referred to the IVF Unit of Yas hospital, between July and December 2017, were enrolled in this crosssectional study. The demographic characteristics of the participants, as well as the serum levels of vitamin D, AMH, and ultrasonic examination of AFC were recorded. Results: Finally, 287 infertile women were included in the analysis with a mean age of 29.95 +/- 4.73 yr (18-45 yr) and a mean Body mass indexof 25.11 +/- 4.41 kg/m(2). The median AMH and vitamin D levels were 3.20 and 22.82 ng/ml, respectively. Considering the cut-off level of 20 ng/ml, 58.7% were vitamin D deficient. Regression analysis showed no association between AMH and vitamin D levels (p = 0.161), even after adjusting for baseline variables (p = 0.182). A total of 120 patients had an AFC < 6 and 164 >= 6, which was not statistically different between the groups with normal level or deficient vitamin D (p = 0.133). Conclusion: The present cross-sectional study showed no significant association between serum levels of vitamin D and AMH or AFC in infertile women, even after adjusting for baseline variables.