Anti-IDH1 Polyclonal Antibody (CABT-L2027) Knockout Validated

Rabbit Anti-Human IDH1 (Ala74~Ile333) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Mouse, Pig
Immunogen
Recombinant fragment corresponding to human IDH1 (Ala74~Ile333)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.2-2 ug/ml; 1:250-2500
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type HepG2 cell lysate. Lane 2: IDH1 knockout HepG2 cell lysate. Predicted MW: 47kDa, Observed MW: 47kDa
Western Blot. Sample. Human HepG2 cell lysate.
Western Blot. Sample. Human Liver lysate.
Western Blot. Sample. Mouse Liver lysate.
Western Blot. Sample. Porcine Liver lysate.

Target


Alternative Names
PICD; IDP; Oxalosuccinate decarboxylase; NADP(+)-specific ICDH; Cytosolic NADP-isocitrate dehydrogenase
Entrez Gene ID
UniProt ID

Product Background


Pathway
2-Oxocarboxylic acid metabolism; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; Biosynthesis of amino acids; Carbon metabolism; Central carbon metabolism in cancer; Citrate cycle (TCA cycle); Citrate cycle (TCA cycle, Krebs cycle); Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate;

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Kato, Y; et al. Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas. BRAIN TUMOR PATHOLOGY 32:3-11(2015).
Stoczynsica-Fidelus, E; Och, W; et al. Spontaneous In Vitro Senescence of Glioma Cells Confirmed by an Antibody Against IDH1(R132H). ANTICANCER RESEARCH 34:2859-2867(2014).

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