General Notes
This product (Catalog No. DPABH-26281) is a rabbit-derived polyclonal antibody raised against human IDH1, targeting the amino acid region 341–414 of the protein. This antibody exhibits cross-reactivity with Human IDH1 from mouse and rat. It has been affinity purified by Protein A. IDH1, also named as PICD and IDP, belongs to the isocitrate and isopropylmalate dehydrogenases family. It is a common feature of a major subset of primary human brain cancers. Its subunit structure is homodimer(PMID:15173171).IDH1 mutation is always heterozygotic and IDH1 functions as a dimer, theoretically there will be 25% each wild type and mutant homo-dimers and 50% hetero-dimers present in the tumor cells(PMID:21079649 ).
DPABH-26281 is suitable for use in Western blot (WB) (1:2,000–1:10,000), IHC (1:2,000–1:8,000), flow cytometry (FC) (0.25 μg per 10^6 cells in a 100 μl suspension) applications.
DPABH-26281 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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