Sulfonamides, BSA-conjugated

Name: Sulfonamides, BSA-conjugated
SKU: DAG-T2798
Rating: 5 (1 reviews)

Regulatory status: For research use only, not for use in diagnostic procedures.

COA

SDS

Datasheet

Summary

Product Overview

Sulfonamides, BSA conjugate

Tag/Conjugate

BSA

Format

Concentrate

Concentration

6mg/ml

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

In chemistry, the sulfonamide functional group (also spelt sulphonamide) is -S(=O)2-NH2, a sulfonyl group connected to an amine group. Relatively speaking this group is unreactive. The amine center is no longer basic. The S-N bond is cleaved only with difficulty. Because of the rigidity of the functional group, sulfonamides are typically crystalline. For this reason, the formation of a sulfonamide is a classic method to convert an amine into a crystalline derivative which can be identified by its melting point. Many important drugs contain the sulfonamide group.

Keywords

Sulfonamide

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References

Genomic Analysis of two NDM-1Providencia stuartiiStrains Recovered from a Single Patient

CURRENT MICROBIOLOGY

Authors: Hoard, Amparo; Montana, Sabrina; Moriano, Alessandro; Fernandez, Jennifer S.; Traglia, German M.; Quiroga, Cecilia; Franchi, Agustina; Cohen, Emilia; Corigliano, Cecilia; Almuzara, Marisa; Ramirez, Maria Soledad

Abstract

In the last years, an increasing number of untreatable infections caused by drug-resistant microbes have impacted the health care system. Worldwide, infections caused by carbapenem-resistant (CR) Gram-negative bacilli have dramatically increased. Among the CR-Gram-negative bacilli, those producing carbapenemases, such as NDM-1, are the main concern. DifferentEnterobacteralesharboring NDM-1 have been reported lately.Providencia stuartii, a member of theMorganellaceaefamily, is ubiquitous in the environment, but is also known to cause nosocomial infections. Here we describe the genomic analysis of two NDM-1- producingP. stuartiistrains recovered from the same patient as well as other carbapenem resistant strains recovered from the same hospital. As a result of the genomic analysis thirteen resistance genes, including three to beta-lactams (bla(OXA-1),bla(TEM-1),bla(NDM-1)), four to aminoglycosides (aphA6, aac(3)-IId, aac(2 ')-Ia,aac(6 ')-Ib-cr5), one to sulfonamides (sul1), two to chloramphenicol (catB3, catA3), one to rifampicin, one to bleomycin (ble), and one to tetracycline (tet(B)) were found. Moreover, a variety of mobile genetic elements, such as insertion sequences, plasmids and phage- related sequences, were found withinP. stuartiigenomes. The spread of carbapenem-resistant isolates remains a significant clinical and public health concern. Therefore, we considered that the detection of CR isolates is an essential step in addressing this problem.

Cu-mediated one-pot three-component synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives

TETRAHEDRON

Authors: Dong, Wei; Ge, Zemei; Wang, Xin; Li, Ridong; Li, Runtao

Abstract

A novel and efficient copper-catalyzed one-pot procedure for the synthesis of 3-N-substituted 1,4,2-benzodithiazine 1,1-dioxide derivatives from 2-halobenzenesulfonamides, amines and CS2 is described. The reaction proceeds through Ullmann-type S-arylation, intramolecular addition of NH2 with C=S and dehydrosulfide, which provides a new and useful strategy for construction of cyclic aromatic sulfonamides. (C) 2020 Elsevier Ltd. All rights reserved.