Human Glucose 6 Phosphate Dehydrogenase Protein

Product Overview

Glucose-6-phosphate1-dehydrogenase (G-6-PDH) (Leuconostoc mesenteroides), Recombinant, Molecularweights: 55kDa (SDS-PAGE), 146kDa (gel filtration), was expressed in E. coli.Does not contain a fusion partner.

Nature

Recombinant

Tag/Conjugate

Unconjugated

Format

Purified, Lyophilized

Concentration

Specific activity:Lot specific IU/mg

Buffer

Not applicable

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Antigen Description

Glucose-6-phosphate dehydrogenase(G6PD or G6PDH) is a cytosolic enzyme in the pentose phosphate pathway (seeimage), a metabolic pathway that supplies reducing energy to cells (such aserythrocytes) by maintaining the level of the co-enzyme nicotinamide adeninedinucleotide phosphate (NADPH). The NADPH in turn maintains the level ofglutathione in these cells that helps protect the red blood cells againstoxidative damage. Of greater quantitative importance is the production ofNADPH for tissues actively engaged in biosynthesis of fatty acids and/orisoprenoids, such as the liver, mammary glands, adipose tissue, and theadrenal glands.

Keywords

G6PD; glucose-6-phosphate dehydrogenase; G6PD1; glucose-6-phosphate 1-dehydrogenase;