Anti-G6PD monoclonal antibody, clone 6F23

Antibody Isotype

IgG1

Clone

6F23

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to human G6PD.

Conjugate

Application Notes

ELISA (1:10000); WB (1:500-1:2000); Immunohistochemistry (1:200-1:1000); Flow Cytometry (1:200-1:400) & The optimal working dilution should be determined by the end user.

Alternative Names

G6PD; glucose-6-phosphate dehydrogenase; glucose-6-phosphate 1-dehydrogenase; G6PD1; glucose-6-phosphate dehydrogenase, G6PD;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.

Pathway

Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of carbohydrates, organism-specific biosystem; Pentose Phosphate Pathway, organism-specific biosystem;