Recombinant M. Tuberculosis Mpt70 Antigen [His, GST]

Name: Recombinant M. Tuberculosis Mpt70 Antigen [His, GST]
SKU: DAGA-182
Rating: 5 (1 reviews)

M. Tuberculosis Mpt70 Antigen, Recombinant protein from E. coli for WB, ELISA

COA

SDS

Datasheet

Summary

Product Overview

N-terminal GST fusion protein with C-terminal 6xHis tagged antigen Mpt70(Rv2875) (M. Tuberculosis/H37Rv)(a.a.1-197) (Genbank Accession No. NP_217391). Major secreted immunogenic proteinMPT70 precursor (see citations below). Also similar to downstream ORFQ10790|MP83_MYCTU|MPT83| MPB83| Rv2873|MT2940|MTCY274.04cell surface lipoprotein MPT83 precursor (lipoprotein P23) (220 aa), FASTA scores: opt: 806, E(): 1.2e-40, (70.25% identity in 185 aa overlap). Belongs to the MPT70 / MPT83family. Generally found as a monomer; homodimer in culture fluids.

Nature

Recombinant

Tag/Conjugate

His, GST

Alternative Names

M. Tuberculosis 63 kDa protein; Mycobacterium tuberculosis 94 kDa protein; Mycobacterium tuberculosis; M. tuberculosis; MTB; TB antigen

Purity

>95% , based on SDS PAGE

Format

Liquid or Lyophilized powder

Concentration

Batch dependent - please inquire should you have specific requirements.

Preservative

None

Reconstitution

Reconstitute the protein with 100 μl of Millipore water.

Antigen Description

Mycobacterium tuberculosis is an obligate pathogenic bacterial species in the family Mycobacteriaceae and the causative agent of tuberculosis First discovered in 1893 by Robert Koch, M. tuberculosis has an unusual, waxy coating on its cell surface (primar

Keywords

M. Tuberculosis 63 kDa protein;Mycobacterium tuberculosis 94 kDa protein;Mycobacterium tuberculosis;M. tuberculosis;MTB;TB antigen

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

M. tuberculosis Antibodies and Antigens

QA & Reviews

Customer Reviews

References

Exploring MDR-TB Inhibitory Potential of 4-Aminoquinazolines asMycobacterium tuberculosis N-Acetylglucosamine-1-Phosphate Uridyltransferase (GlmU(MTB)) Inhibitors

CHEMISTRY & BIODIVERSITY

Authors: Patel, Harun M.; Palkar, Mahesh; Karpoormath, Rajshekhar

Abstract

Drug resistance tuberculosis is one of the challenging tasks that dictates the desperate need for the development of new antitubercular agents which operatevianovel modes of action. Here, we are reporting on 4-aminoquinazolines asM. tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU(MTB)) inhibitors to overcome the problem of the MDR-TB. Amongst the synthesized compounds, two of them were observed to be the effective compounds of the series (IC50=6.4 mu M (H37Rv), MIC=25 mu M (MDR-TB) and IC50=2.9 mu M (H37Rv), MIC=6.25 mu M (MDR-TB), respectively).

Tuberculosis in elephants: Origins and evidence of interspecies transmission

TUBERCULOSIS

Authors: Paudel, Sarad; Sreevatsan, Srinand

Abstract

Tuberculosis (TB) is a devastating disease in elephants caused by either Mycobacterium tuberculosis or M. bovis. It is an ancient disease, and TB in elephants was first reported over two millennia ago in Sri Lanka. Outbreaks of TB worldwide, in captive and free-ranging elephant populations, have been recorded. Interspecies transmission of TB among elephants and humans has been confirmed in several geographic localities using spoligotyping, MIRU-VNTR analysis, and/or comparative genomics. Active surveillance of TB in wild and captive elephants and their handlers is necessary to prevent TB transmission at the elephant-human interface and to aid in the conservation of Asian and African elephants. In this review, we present an overview of diagnosis, reports of TB outbreaks in the past 25 years, TB in wild elephants, its transmission, and possible prevention and control strategies that can be applied at the elephant-human interface.