HIV type 1 Nef (DAG-P2708)

HIV type 1 Nef (aa 3 - 190), recombinant protein from E. coli Datasheet

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Product Overview
HIV1 Nef full length protein
This product reacts strongly with human HIV positive serum.
> 95 % by SDS-PAGE.Purity is >95% as determined by SDS-PAGE and spectrophotometry.
Preservative: None Constituents: 10mM Sodium Carbonate, 14mM Beta mercaptoethanol, 10mM EDTA, pH 8
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Preservative: None Constituents: 10mM Sodium Carbonate, 14mM Beta mercaptoethanol, 10mM EDTA, pH 8
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic
Antigen Description
Nef is a early protein that appears to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Nef enhances virus infectivity and pathogenicity. It down modulates surface MHC I molecules and internalized molecules are sequested to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.
C terminal core protein; F protein; Nef; Negative factor; p27; HIV1 Nef


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