HIV type 1 Nef (DAG-P2507)
HIV type 1 Nef (aa 1 - 206), recombinant protein from E. coli
Datasheet
Product Overview
HIV1 Nef full length protein
Nature
Recombinant
Tag/Conjugate
Unconjugated
Molecular Weight
26 kDa including tags
Purity
>90% by SDS-PAGE.The final product was refolded using temperature shift inclusion body refolding technology and chromatographically purified.
Format
Liquid
Buffer
pH: 8.00Constituent: 0.32% Tris HClContains NaCl, KCl, EDTA, arginine, DTT and Sucrose.
Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -80°C. Avoid freeze / thaw cycle. pH: 8.00Constituent: 0.32% Tris HClContains NaCl, KCl, EDTA, arginine, DTT and Sucrose.
Introduction
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic
Antigen Description
Nef is a early protein that appears to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Nef enhances virus infectivity and pathogenicity. It down modulates surface MHC I molecules and internalized molecules are sequested to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.
Keywords
C terminal core protein; F protein; Nef; Negative factor; p27; HIV1 Nef
Citations
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