Anti-SQSTM1 monoclonal antibody [DyLight® 488] (DCABH-3617)

Rabbit anti-Human SQSTM1 monoclonal antibody for FC, ICC/IF Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS5955
Species Reactivity
Human
Immunogen
Synthetic peptide corresponding to residues in Human SQSTM1/ p62 (UniProt ID: Q13501).
Conjugate
DyLight® 488

Applications


Application Notes
Flow Cyt: 1/100; ICC/IF: 1/100.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
SQSTM1; sequestosome 1; OSIL, oxidative stress induced like , Paget disease of bone 3 , PDB3; sequestosome-1; A170; p60
Entrez Gene ID
UniProt ID

Product Background


Pathway
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; IL1-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; Interleukin-1 signaling, organism-specific biosystem; NF-kB is activated and signals survival, organism-specific biosystem; NRIF signals cell death from the nucleus, organism-specific biosystem;

Citations


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References


Shen, CC; Wang, WZ; et al. Chloroquine blocks the autophagic process in cisplatin-resistant osteosarcoma cells by regulating the expression of p62/SQSTM1. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:448-456(2013).
Narendra, DP; Kane, LA; et al. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. AUTOPHAGY 6:1090-1106(2010).

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