Anti-PLAT (aa 250-350) polyclonal antibody

BackgroundAlthough lung protection with low tidal volume and limited plateau pressure (P-plat) improves survival in acute respiratory distress syndrome patients (ARDS), the best way to set positive end-expiratory pressure (PEEP) is still debated.MethodsThis study aimed to compare two strategies using individual PEEP based on a maximum P-plat (28-30 cmH(2)O, the Express group) or on keeping end-expiratory transpulmonary pressure positive (0-5 cmH(2)O, P-Lexpi group). We estimated alveolar recruitment (Vrec), end-expiratory lung volume and alveolar distension based on elastance-related end-inspiratory transpulmonary pressure (P-L,P-EL).ResultsNineteen patients with moderate to severe ARDS (PaO2/FiO(2)<150mmHg) were included with a baseline PEEP of 7.01.8 cmH(2)O and a PaO2/FiO(2) of 91.2 +/- 31.2mmHg. PEEP and oxygenation increased significantly from baseline with both protocols; PEEP Express group was 14.2 +/- 3.6 cmH(2)O versus 16.7 +/- 5.9 cmH(2)O in P-Lexpi group. No patient had the same PEEP with the two protocols. Vrec was higher with the latter protocol (299 [0 to 875] vs. 222 [47 to 483] ml, p=0.049) and correlated with improved oxygenation (R-2=0.45, p=0.002). Two and seven patients in the Express and P(L,expi)There is a great heterogeneity of P-Lexpi when P-plat is used to titrate PEEP but with limited risk of over-distension. A PEEP titration for a moderate positive level of P-Lexpi might slightly improve alveolar recruitment and oxygenation but increases the risk of over-distension in one-third of patients.

The aim of the present study is to compare the performance of the Inclined Solar Panel Basin (ISPB) still integrated with (active mode) and without (passive mode) Flat Plat Collector (FPC). The maximum yield of 4.3 and 7.9 kg/day is produced from the passive and active mode respectively. The daily thermal and exergy effectiveness of the passive mode is 39.82% and 2.9% and, the active mode is 46.87% and 6.6%, respectively. For the active mode the daily yield, thermal and exergy efficiencies are increased and the panel effectiveness is decreased. An active mode increases the daily fresh water production rate, thermal and exergy effectiveness up to 44.63, 24.91 and 55.68% respectively than the passive mode.