IGHA2; immunoglobulin heavy constant alpha 2 (A2m marker); IgA2; constant region of heavy chain of IgA2; immunoglobulin alpha 2 (A2M marker)
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The IgE Blocking Activity Induced by Dermatophagoides pteronyssinus Subcutaneous Immunotherapy Does Not Correlate with Specific IgA but with IgG4 in both Serum and Saliva
Int Arch Allergy Immunol2021 JulPubMed ID: 34280916Read Article
Applications: ELISA Reactive species: Human
"Abstract: Background: The role of salivary-specific IgG4 and IgA in subcutaneous immunotherapy (SCIT) is not well defined. We aimed to investigate the change of IgG4 and IgA in both serum and saliva and their correlations with IgE-blocking-factor (IgE-BF) during SCIT. Method: 307 Dermatophagoides pteronyssinus (DP) allergic rhinitis and/or asthma patients were recruited for this study. 286 patients received DP-SCIT for 1 year. Twenty-one patients received only symptomatic treatment. DP-, Der p 1-, and Der p 2-specific IgE in serum, specific-IgG4 and Der p 2-specific IgA1 and IgA2 in both serum and saliva were measured at timepoints 0, 4, and 12 months during DP-SCIT. Correlation between salivary and serological IgG4, IgA, and their correlation with DP-specific IgE-BF measured in serum was evaluated. Results: During DP-SCIT, the allergen-specific IgG4 in both saliva and serum increased and correlated significantly, the correlation becomes stronger over the treatment time. DP-specific IgE-BF significantly correlated with DP-specific IgG4 in serum (p < 0.0001) at different timepoints and in saliva at 12 months of SCIT (p < 0.01). No change in Der p 2-specific IgA during DP-SCIT was observed, and the IgA in serum did not correlate with IgA in saliva. There was no correlation between DP IgE-BF and Der p 2-specific IgA in serum or saliva. The control group did not exhibit significant changes in any antibody level measured." Article snippet: Mouse mAb to IgA1 (clone C3507B5; Creative Diagnostics, USA) or IgA2 (clone B9605D3; Creative Diagnostics, USA) were used at 0.5 μg/mL for detection and revealed by HRP labeled goat anti-mouse IgG (*) followed by Tetramethylbenzidine for visualizing.
Figure 1. The change of allergen-specific IgA2 in serum during the treatment.
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