Anti-GRIN1 monoclonal antibody, clone S2KIM

Clone

S2KIM

Species Reactivity

Mouse; Rat

Conjugate

Application Notes

WB: 1:1000

Alternative Names

Glutamate receptor ionotropic; NMDA 1; GluN1; Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; Grin1; Nmdar1

Entrez Gene ID

UniProt ID

Antigen Description

The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1-subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.

Pathway

Activation of NMDA receptor upon glutamate binding and postsynaptic events; Alcoholism; Alzheimer's disease; Amphetamine addiction; Amyotrophic lateral sclerosis (ALS); CREB phosphorylation through the activation of CaMKII; CREB phosphorylation through the activation of Ras; Calcium signaling pathway;